BOK (gene)

BCL2-related ovarian killer
Identifiers
Symbols BOK; BCL2L9; BOKL; MGC4631
External IDs OMIM605404 MGI1858494 HomoloGene9632 GeneCards: BOK Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 666 51800
Ensembl ENSG00000176720 ENSMUSG00000026278
UniProt Q9UMX3 Q3TH93
RefSeq (mRNA) NM_032515 NM_016778.2
RefSeq (protein) NP_115904 NP_058058.1
Location (UCSC) Chr 2:
242.5 – 242.51 Mb
Chr 1:
95.58 – 95.59 Mb
PubMed search [1] [2]

Bcl-2-related ovarian killer protein is a protein that in humans is encoded by the BOK gene.[1][2][3][4]

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains all four BCL-2 like domains (BH1, 2, 3 and 4) and is a pro-apoptotic BCL-2 protein identified in the ovary.[4]

References

  1. ^ Hsu SY, Kaipia A, McGee E, Lomeli M, Hsueh AJ (Dec 1997). "Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members". Proc Natl Acad Sci U S A 94 (23): 12401–6. doi:10.1073/pnas.94.23.12401. PMC 24966. PMID 9356461. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24966. 
  2. ^ Zhang H, Holzgreve W, De Geyter C (Nov 2000). "Evolutionarily conserved Bok proteins in the Bcl-2 family". FEBS Lett 480 (2–3): 311–3. doi:10.1016/S0014-5793(00)01921-9. PMID 11034351. 
  3. ^ Yakovlev AG, Di Giovanni S, Wang G, Liu W, Stoica B, Faden AI (Jun 2004). "BOK and NOXA are essential mediators of p53-dependent apoptosis". J Biol Chem 279 (27): 28367–74. doi:10.1074/jbc.M313526200. PMID 15102863. 
  4. ^ a b "Entrez Gene: BOK BCL2-related ovarian killer". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=666. 

Further reading