BOK (gene)
Bcl-2-related ovarian killer protein is a protein that in humans is encoded by the BOK gene.[1][2][3][4]
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains all four BCL-2 like domains (BH1, 2, 3 and 4) and is a pro-apoptotic BCL-2 protein identified in the ovary.[4]
References
- ^ Hsu SY, Kaipia A, McGee E, Lomeli M, Hsueh AJ (Dec 1997). "Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members". Proc Natl Acad Sci U S A 94 (23): 12401–6. doi:10.1073/pnas.94.23.12401. PMC 24966. PMID 9356461. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24966.
- ^ Zhang H, Holzgreve W, De Geyter C (Nov 2000). "Evolutionarily conserved Bok proteins in the Bcl-2 family". FEBS Lett 480 (2–3): 311–3. doi:10.1016/S0014-5793(00)01921-9. PMID 11034351.
- ^ Yakovlev AG, Di Giovanni S, Wang G, Liu W, Stoica B, Faden AI (Jun 2004). "BOK and NOXA are essential mediators of p53-dependent apoptosis". J Biol Chem 279 (27): 28367–74. doi:10.1074/jbc.M313526200. PMID 15102863.
- ^ a b "Entrez Gene: BOK BCL2-related ovarian killer". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=666.
Further reading
- Inohara N, Ekhterae D, Garcia I et al. (1998). "Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL". J. Biol. Chem. 273 (15): 8705–10. doi:10.1074/jbc.273.15.8705. PMID 9535847.
- Leo CP, Hsu SY, Chun SY et al. (1999). "Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary". Endocrinology 140 (12): 5469–77. doi:10.1210/en.140.12.5469. PMID 10579309.
- Zhang H, Huang Q, Ke N et al. (2000). "Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms". J. Biol. Chem. 275 (35): 27303–6. doi:10.1074/jbc.M002846200. PMID 10811653.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Soleymanlou N, Wu Y, Wang JX et al. (2005). "A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia". Cell Death Differ. 12 (5): 441–52. doi:10.1038/sj.cdd.4401593. PMID 15775999.
- Gao S, Fu W, Dürrenberger M et al. (2005). "Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3". Cell. Mol. Life Sci. 62 (9): 1015–24. doi:10.1007/s00018-005-4543-3. PMID 15868100.
- Bartholomeusz G, Wu Y, Ali Seyed M et al. (2006). "Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis". Mol. Carcinog. 45 (2): 73–83. doi:10.1002/mc.20156. PMID 16302269.
- Rodriguez JM, Glozak MA, Ma Y, Cress WD (2006). "Bok, Bcl-2 related ovarian killer, is cell cycle regulated and sensitizes to stress-induced apoptosis". J. Biol. Chem. 281 (32): 22729–35. doi:10.1074/jbc.M604705200. PMC 2134790. PMID 16772296. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2134790.